GSK2269557 (free base)

Name	GSK2269557 (free base)
Synonyms	CS-2340 GSK2269557 (free base) Nemiralisib(GSK2269557) gsk2269557(Nemiralisib) PI3Kδ inhibitor GS2269557 Nemiralisib (GSK2269557 free base) 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole 1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]-
CAS	1254036-71-9

Molecular Formula	C26H28N6O
Molar Mass	440.54
Density	1.281±0.06 g/cm3(Predicted)
Boling Point	706.2±70.0 °C(Predicted)
Solubility	DMSO: ≥ 31 mg/mL
pKa	12.90±0.40(Predicted)
Storage Condition	-20℃
In vivo study	GSK-2269557 has a relatively low oral bioavailability (F = 2%), with a clearance of 28 mL/min/kg, but a high volume distribution of 6.3 L/kg. 0.3-1 μMGSK-2269557 induced concentration-dependent prolongation of QT interval and T-p-e, and 1 μm GSK-2269557 resulted in prolongation of the ORS wave, during which no tip-torsion arrhythmia was observed. In an acute OVA disease model in brown Norway rats, Th2 drives lung inflammation and is GSK-2269557 able to protect the lungs from eosinophil recruitment (ED50=67 μg/kg), and concentration-dependently reduce recruitment and IL-13 of all leukocyte subpopulations.

Last Update：2024-01-02 23:10:35

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Product Name: GSK2269557 (free base) Visit Supplier Webpage Request for quotation
CAS: 1254036-71-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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GSK2269557 (free base)

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